Futurama and The Simpsons belong to the same corporate entity, but they exist in different worlds; Homer, Marge and the kids exist as fictional characters in Futurama's future. Although that show is dead and The Simpsons long past their best days, it seems inevitable that Bongo Comics would have them meet, in this two-issue special. Note the title, which parodies many of DC and Marvels in-house crossovers.

In 2005, they met again, along with characters from much of western literature and several unlicensed DC and Marvel superheroes.